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INSIGHTS

Writing on outcome measurement.

Whitepapers, working notes and, in time, our published research — on how clinical outcomes are measured, and how that measurement earns trust.

Whitepaper
August 12, 2026

When the Measure Moves

A decade of peer-reviewed evidence on how rater bias and inconsistent scoring erode CNS trial data — what it costs in statistical power, and which mitigations demonstrably work.

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Whitepaper
August 11, 2026

Lost in Migration

Every instrument on a screen carries a validation history earned on paper. What the 2023 ISPOR framework actually requires, where equivalence breaks down, and a migration checklist.

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Whitepaper
August 10, 2026

Meaningful to Whom?

Minimal clinically important differences decide sample sizes, responder definitions and reimbursement arguments — yet two thirds cannot be credibility-assessed. What a defensible threshold looks like.

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